08-12-17| Epilepsy drug effective for children younger than 2 years

08 December 2017
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The 2017 American Epilepsy Society Annual Meeting which took place in Washington DC last week has found that Clobazam is effective for patients with refractory epilepsy who are aged under two years.

The drug is approved by the US Food and Drug Administration as therapy for Lennox-Gastaut syndrome for young patients in this age range . Researchers conducted a review at Boston Children's Hospital from October 2011 to December 2016 and identified 155 patients aged under 2 years who received clobazam.

According to Neurology Advisor.com the researchers noted that:

  • 16% of patients had a 50% reduction in seizures.
  • 12% had no change in seizure frequency.
  • 14% experienced worsening of seizure frequency.
  • 26% of patients became seizure-free.
  • 7% of patients discontinued treatment: 4% due to adverse events, and 3% due to lack of efficacy. Common adverse effects were weakness, somnolence, and irritability, followed by drowsiness and dizziness, which were less common.


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